Apatos

  • Apatos
  • Apatos
  • Apatos
  • Apatos
  • Apatos
  • Apatos
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  • Tissue origin :
    Apatos Mix: cortico-cancellous heterologous bone mix
    Apatos Cortical: heterologous cortical bone
  • Tissue collagen :
    Degraded
  • Physical form :
    Radiopaque granules of mineral hydroxyapatite
  • Composition :
    Apatos Mix: 100% cortico-cancellous mix
    Apatos Cortical: 100% cortical bone
  • Granulometry :
    600-1000 µm
  • Re-entry time :
    About 5 months
  • Packaging :
    Mix | Vial: 0.5 g, 1.0 g, 2.0 g
    Cortical | Vial: 0.5 g, 1.0 g
  • Product codes :
    Mix | A1005FS | 1 Vial | 0.5 g | Porcine
    Mix | A1005FE | 1 Vial | 0.5 g | Equine
    Mix | A1010FS | 1 Vial | 1.0 g | Porcine
    Mix | A1010FE | 1 Vial | 1.0 g | Equine
    Mix | A1020FS | 1 Vial | 2.0 g | Porcine
    Mix | A1020FE | 1 Vial | 2.0 g | Equine
    Cortical | AC1005FS | 1 Vial | 0.5 g | Porcine
    Cortical | AC1010FS | 1 Vial | 1.0 g | Porcine
  • GMDN code : 38746
Characteristics
Apatos is a biocompatible1, osteoconductive2 biomaterial of heterologous origin with characteristics similar to mineralized human bone3,4; it can therefore be used as an alternative to autologous bone. The natural microporous consistency of Apatos facilitates the formation of new bone tissue in bone defect area5, accelerating the process. Apatos nanocrystalline hydroxyapatite is available in cortical and mixed granules.
Handling
Apatos must always be hydrated and thoroughly mixed with a few drops of sterile saline; it can also be mixed with patient's blood. Finally it can be mixed if necessary with the drug selected for surgery; the mixture thus obtained should be positioned with a sterile spatula or syringe for biomaterials.
Clinical indications
Apatos is a universal filler, that can be used to treat peri-implant defects and two-wall defects6,7. Because of its granulometry, Apatos cannot be used in narrow defects, but it fits well in big sockets, e.g. after molar extractions8. Both types of sinus lift (with crestal or lateral access)4,9 can be performed with Apatos as bone substitute, as well as surgeries for horizontal regenerations. Apatos Cortical is characterized by a very long resorption time, guaranteeing optimal preservation of the graft volume. When needed, Apatos grafts can be protected with OsteoBiol® Evolution membrane or stabilized with Cortical Lamina.
Bibliography
1 TRUBIANI O, SCARANO A, ORSINI G, DI IORIO D, D'ARCANGELO C, PICCIRILLI M, SIGISMONDO M, CAPUTI S
THE PERFORMANCE OF HUMAN PERIODONTAL LIGAMENT MESENCHYMAL STEM CELLS ON XENOGENIC BIOMATERIALS
INT J IMMUNOPATHOL PHARMACOL, 2007 JAN-MAR; 20(1 SUPPL 1):87-91

2 BRUNELLI G, SOLLAZZO V, CARINCI F, PALMIERI A, GIRARDI A, MONGUZZI R
OSTEOBIOL® INFLUENCES OSTEOGENIC DIFFERENTIATION OF ADIPOSE DERIVED STEM CELLS
EUR J INFLAMM, 2011, VOL. 9, NO. 3(S), 103-107

3 ORSINI G, SCARANO A, PIATTELLI M, PICCIRILLI M, CAPUTI S, PIATTELLI A
HISTOLOGIC AND ULTRASTRUCTURAL ANALYSIS OF REGENERATED BONE IN MAXILLARY SINUS AUGMENTATION USING A PORCINE BONE-DERIVED BIOMATERIAL
J PERIODONTOL 2006 DEC;77(12):1984-90

4 SCARANO A, PIATTELLI A, PERROTTI V, MANZON L, IEZZI G
MAXILLARY SINUS AUGMENTATION IN HUMANS USING CORTICAL PORCINE BONE: A HISTOLOGICAL AND HISTOMORPHOMETRICAL EVALUATION AFTER 4 AND 6 MONTHS
CLIN IMPLANT DENT RELAT RES, 2011 MAR; 13(1):13-18

5 IEZZI G, DEGIDI M, PIATTELLI A, MANGANO C, SCARANO A, SHIBLI JA, PERROTTI V
COMPARATIVE HISTOLOGICAL RESULTS OF DIFFERENT BIOMATERIALS USED IN SINUS AUGMENTATION PROCEDURES: A HUMAN STUDY AT 6 MONTHS
CLIN ORAL IMPLANTS RES, 2012 DEC;23(12):1369-76 EPUB 2011 NOV 2

6 BARONE A, AMERI S, COVANI U
IMMEDIATE POSTEXTRACTION IMPLANTS: TREATMENT OF RESIDUAL PERI-IMPLANT DEFECTS. A RETROSPECTIVE ANALYSIS
EUR J IMPLANT PROSTHODONTICS, 2006,2: 99-106

7 BARONE A, TOTI P, QUARANTA A, DERCHI G, COVANI U
THE CLINICAL OUTCOMES OF IMMEDIATE VERSUS DELAYED RESTORATION PROCEDURES ON IMMEDIATE IMPLANTS: A
COMPARATIVE COHORT STUDY FOR SINGLE-TOOTH REPLACEMENT
CLIN IMPLANT DENT RELAT RES, 2014 MAY 22 EPUB AHEAD OF PRINT

8BARONE A, TOTI P, QUARANTA A, ALFONSI F, CUCCHI A, CALVO GUIRADO JL, NEGRI B, DI FELICE R, COVANI U
VOLUMETRIC ANALYSIS OF REMODELLING PATTERN AFTER RIDGE PRESERVATION COMPARING USE OF TWO TYPES OF XENOGRAFTS. A MULTICENTRE RANDOMIZED CLINICAL TRIAL CLINICAL ORAL IMPLANTS RESEARCH, 2015 FEB 26 EPUB AHEAD OF PRINT

9SCARANO A, PIATTELLI A, ASSENZA B, QUARANTA A, PERROTTI V, PIATTELLI M, IEZZI G
PORCINE BONE USED IN SINUS AUGMENTATION PROCEDURES: A 5-YEAR RETROSPECTIVE CLINICAL EVALUATION
J ORAL MAXILLOFAC SURG, 2010 AUG; 68(8):1869-73
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