Gen-Os®

  • Gen-Os
  • Gen-Os
  • Gen-Os
  • Gen-Os
  • Gen-Os
  • Gen-Os
  • Gen-Os
  • Gen-Os
  • Gen-Os
  • Gen-Os
  • Gen-Os
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  • Tissue origin :
    Cortico-cancellous heterologous bone mix
  • Tissue collagen :
    Preserved
  • Physical form :
    Slightly radiopaque granules
  • Composition :
    100% granulated mix
  • Granulometry :
    250-1000 µm
  • Re-entry time :
    4/5 months, depending on grafting site characteristics
  • Packaging :
    Vial: 0.25 g, 0.5 g, 1.0 g, 2.0 g
  • Product codes :
    M1052FS | 1 Vial | 0.25 g | Porcine
    M1052FE | 1 Vial | 0.25 g | Equine
    M1005FS | 1 Vial | 0.5 g | Porcine
    M1005FE | 1 Vial | 0.5 g | Equine
    M1010FS | 1 Vial | 1.0 g | Porcine
    M1010FE | 1 Vial | 1.0 g | Equine
    M1020FS | 1 Vial | 2.0 g | Porcine
    M1020FE | 1 Vial | 2.0 g | Equine
  • GMDN code : 38746
Characteristics
A natural replicate of autologous bone, Gen-Os® conserves the same intimate structures1 (matrix and porous form) and presents a highly osteoconductive properties2. It is biocompatible and bioavailable, as recognized by tests made according to the ISO 10993 method conducted at Eurofins Biolab.
Gen-Os® is gradually resorbable and provides support in bone neoformation helping to preserve the original graft shape and volume (osteoconductive property)3,4.
Moreover, thanks to its collagen content, the product facilitates blood clotting and the subsequent invasion of repairing and regenerative cells, favouring restitutio ad integrum of missing bone. Because of its marked hydrophilia5, it can function as a carrier for selected medications and drugs6.
Handling
Gen-Os® must always be hydrated and thoroughly mixed with a few drops of sterile physiological solution to activate its collagen matrix and to enhance its adhesivity; it can also be mixed with patient's blood. If necessary it can as well be mixed with the drug selected for surgery.
Clinical indications
Gen-Os®, a cortico-cancellous bone mix, has been the first product developed with the Tecnoss® innovative biotechnology and, due to its universal use, still is today the most demanded from the market.
Gen-Os® has been successfully used and documented for alveolar ridge preservation7 in combination withEvolution membranes: the application of this biomaterial limits significantly the alveolar ridge width reduction that would naturally occur with spontaneous healing, preserving thus the alveolar ridge volume and allowing a correct second stage implant placement8.
Gen-Os® is also indicated for lateral access maxillary sinus liftâ4,9 and dehiscence regeneration10, always in association with Evolution membranes.
Ongoing studies are also proving its effectiveness in periodontal regeneration of deep intrabony defects. Due to its collagen content, once hydrated Gen-Os® becomes very sticky and hydrophylic5: it combines therefore extremely well with blood and is very stable once applied into the grafting site. Its cortico-cancellous composition allows a progressive resorption of osteoclastic type, with in parallel a similar rate of new bone formation2: these unique properties allow a very good graft volume preservation, a healthy new bony tissue and ultimately, a successful implant rehabilitation.
Advantages
Gen-Os® expands up to 50% in volume after hydration with sterile saline: hydrated collagen contained in each granule also increases sensibly the biomaterial adhesivity.
Bibliography
1 FIGUEIREDO M, HENRIQUES J, MARTINS G, GUERRA F, JUDAS F, FIGUEIREDO H
PHYSICOCHEMICAL CHARACTERIZATION OF BIOMATERIALS COMMONLY USED IN DENTISTRY AS BONE SUBSTITUTES -
COMPARISON WITH HUMAN BONE
J BIOMED MATER RES B APPL BIOMATER, 2010 FEB; 92(2):409-19

2 NANNMARK U, SENNERBY L
THE BONE TISSUE RESPONSES TO PREHYDRATED AND COLLAGENATED CORTICO-CANCELLOUS PORCINE BONE
GRAFTS: A STUDY IN RABBIT MAXILLARY DEFECTS
CLIN IMPLANT DENT RELAT RES, 2008 DEC;10(4):264-70. EPUB 2008 JAN 30

3 CRESPI R, CAPPARÈ P, ROMANOS GE, MARIANI E, BENASCIUTTI E, GHERLONE E
CORTICOCANCELLOUS PORCINE BONE IN THE HEALING OF HUMAN EXTRACTION SOCKETS: COMBINING HISTOMORPHOMETRY WITH OSTEOBLAST GENE EXPRESSION PROFILES IN VIVO
INT J ORAL MAXILLOFAC IMPLANTS, 2011 JUL-AUG; 26(4):866-72

4 CASSETTA M, PERROTTI V, CALASSO S, PIATTELLI A, SINJARI B, IEZZI G
BONE FORMATION IN SINUS AUGMENTATION PROCEDURES USING AUTOLOGOUS BONE, PORCINE BONE, AND A 50 :
50 MIXTURE: A HUMAN CLINICAL AND HISTOLOGICAL EVALUATION AT 2 MONTHS
CLIN ORAL IMPLANTS RES, 2014 MAY 26 EPUB AHEAD OF PRINT

5 FIGUEIREDO A, COIMBRA P, CABRITA A, GUERRA F, FIGUEIREDO M
COMPARISON OF A XENOGENEIC AND AN ALLOPLASTIC MATERIAL USED IN DENTAL IMPLANTS IN TERMS OF
PHYSICO-CHEMICAL CHARACTERISTICS AND IN VIVO INFLAMMATORY RESPONSE
MATER SCI ENG C MATER BIOL APPL, 2013 AUG 1;33(6):3506-13

6 FISCHER KR, STAVROPOULOS A, CALVO GUIRADO JL, SCHNEIDER D, FICKL S
INFLUENCE OF LOCAL ADMINISTRATION OF PAMIDRONATE ON EXTRACTION SOCKET HEALING - A HISTOMORPHOMETRIC
PROOF-OF-PRINCIPLE PRE-CLINICAL IN VIVO EVALUATION
CLIN ORAL IMPLANTS RES, 2014 SEP 15 EPUB AHEAD OF PRINT

7 FESTA VM, ADDABBO F, LAINO L, FEMIANO F, RULLO R
PORCINE-DERIVED XENOGRAFT COMBINED WITH A SOFT CORTICAL MEMBRANE VERSUS EXTRACTION ALONE FOR
IMPLANT SITE DEVELOPMENT: A CLINICAL STUDY IN HUMANS
CLIN IMPLANT DENT RELAT RES, 2011 NOV 14, EPUB AHEAD OF PRINT

8 CARDAROPOLI D, CARDAROPOLI G
PRESERVATION OF THE POSTEXTRACTION ALVEOLAR RIDGE: A CLINICAL AND HISTOLOGIC STUDY
INT J PERIODONTICS RESTORATIVE DENT, 2008 OCT; 28(5):469-77

9 BARONE A, CRESPI R, NICOLI ALDINI N, FINI M, GIARDINO R, COVANI U
MAXILLARY SINUS AUGMENTATION: HISTOLOGIC AND HISTOMORPHOMETRIC ANALYSIS
INT J ORAL MAXILLOFAC IMPLANTS, 2005, 20: 519-525

10 BOTTINI LP, RICCI L, PIATTELLI A, PERROTTI V, IEZZI G
BUCCO-LINGUAL CRESTAL BONE CHANGES AROUND IMPLANTS IMMEDIATELY PLACED IN FRESH SOCKETS IN ASSOCIATION OR NOT WITH PORCINE BONE: A NON-BLINDED RANDOMIZED CONTROLLED TRIAL IN HUMANS
J PERIODONTOL, 2012 OCT 29, EPUB AHEAD OF PRINT
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