OsteoBiol ®

Case Reports

Videos

Tissue origin :
Apatos Mix: cortico-cancellous heterologous bone mix
Apatos Cortical: heterologous cortical bone
Tissue collagen :
Degraded
Composition :
Apatos Mix: 100% cortico-cancellous mix
Apatos Cortical: 100% cortical bone
Granulometry :
600-1000 µm
1000-2000 µm
Re-entry time :
About 5 months
Packaging :
Mix | Vial: 0.5 g, 1.0 g, 2.0 g
Cortical | Vial: 0.5 g, 1.0 g
GMDN code : 46425

Characteristics: Apatos is a biocompatible^(1,2), osteoconductive^(3,4) biomaterial of heterologous origin with characteristics similar to mineralized human bone⁽⁵⁾; it can therefore be used as an alternative to autologous bone. The natural microporous consistency of Apatos facilitates the formation of new bone tissue in bone defect area⁽⁶⁾, accelerating the process. Apatos microcrystalline hydroxyapatite is available in cortical and mixed granules.
Clinical indications: Apatos is a universal filler, that can be used to treat peri-implant defects and two-wall defects^(7,8). Because of its granulometry, Apatos cannot be used in narrow defects, but it fits well in big sockets, e.g. after molar extractions⁽⁹⁾. Both sinus lift procedures (with crestal or lateral access)^(2,10) can be performed with Apatosas bone substitute, as well as surgeries for horizontal regenerations.
Apatos Cortical is characterized by a very long resorption time⁽¹¹⁾, guaranteeing adequate preservation of the grafted volume. When needed, Apatos grafts can be protected with OsteoBiol® Evolution membrane⁽¹²⁾ or stabilized with Cortical Lamina.

The above clinical information is based on the experience of expert surgeons.
Bibliography: ¹ TRUBIANI O, SCARANO A, ORSINI G, DI IORIO D, D'ARCANGELO C, PICCIRILLI M, SIGISMONDO M, CAPUTI S
THE PERFORMANCE OF HUMAN PERIODONTAL LIGAMENT MESENCHYMAL STEM CELLS ON XENOGENIC BIOMATERIALS
INT J IMMUNOPATHOL PHARMACOL, 2007 JAN-MAR; 20(1 SUPPL 1):87-91

² ORSINI G, SCARANO A, PIATTELLI M, PICCIRILLI M, CAPUTI S, PIATTELLI A
HISTOLOGIC AND ULTRASTRUCTURAL ANALYSIS OF REGENERATED BONE IN MAXILLARY SINUS AUGMENTATION USING A PORCINE BONE-DERIVED BIOMATERIAL
J PERIODONTOL, 2006 DEC;77(12):1984-90

³ BRUNELLI G, SOLLAZZO V, CARINCI F, PALMIERI A, GIRARDI A, MONGUZZI R
OSTEOBIOL® INFLUENCES OSTEOGENIC DIFFERENTIATION OF ADIPOSE DERIVED STEM CELLS
EUR J INFLAMM, 2011, VOL. 9, NO. 3(S), 103-107

⁴ CAKIR M, KARACA IR, AYSEGÜL F, KAYMAZ F, BOZKAYA S
EXPERIMENTAL EVALUATION OF THE EFFECTS OF ANKAFERD BLOOD STOPPER AND COLLAGENATED HETEROLOGOUS BONE GRAFT ON BONE HEALING IN SINUS FLOOR AUGMENTATION
CLIN ORAL IMPLANTS RES, 2015 MAR-APR;30(2):279-85

⁵ KOLMAS J, SZWAJA M, KOLODZIEJSKI W
SOLID-STATE NMR AND IR CHARACTERIZATION OF COMMERCIAL XENOGENEIC BIOMATERIALS USED AS BONE SUBSTITUTES
J PHARM BIOMED ANAL, 2012 MAR 5;61:136-41

⁶ BARONE A, TOTI P, QUARANTA A, ALFONSI F, CUCCHI A, NEGRI B, DI FELICE R, MARCHIONNI S, CALVO GUIRADO JL, COVANI U, NANNMARK U
CLINICAL AND HISTOLOGICAL CHANGES AFTER RIDGE PRESERVATION WITH TWO XENOGRAFTS: PRELIMINARY RESULTS FROM A MULTICENTER RANDOMIZED CONTROLLED CLINICAL TRIAL
J CLIN PERIODONTOL, 2017 FEB;44(2):204-214

⁷ BARONE A, AMERI S, COVANI U
IMMEDIATE POSTEXTRACTION IMPLANTS: TREATMENT OF RESIDUAL PERI-IMPLANT DEFECTS. A RETROSPECTIVE ANALYSIS
EUR J IMPLANT PROSTHODONTICS, 2006,2: 99-106

⁸ BARONE A, TOTI P, QUARANTA A, DERCHI G, COVANI U
THE CLINICAL OUTCOMES OF IMMEDIATE VERSUS DELAYED RESTORATION PROCEDURES ON IMMEDIATE IMPLANTS: A COMPARATIVE COHORT STUDY FOR SINGLE-TOOTH REPLACEMENT
CLIN IMPLANT DENT RELAT RES, 2015 DEC;17(6):1114-26

⁹ BARONE A, TOTI P, QUARANTA A, ALFONSI F, CUCCHI A, CALVO GUIRADO JL, NEGRI B, DI FELICE R, COVANI U
VOLUMETRIC ANALYSIS OF REMODELLING PATTERN AFTER RIDGE PRESERVATION COMPARING USE OF TWO TYPES OF XENOGRAFTS. A MULTICENTRE RANDOMIZED CLINICAL TRIAL
CLIN ORAL IMPLANTS RES, 2016 NOV;27(11):E105-E115

¹⁰ IEZZI G, DEGIDI M, PIATTELLI A, MANGANO C, SCARANO A, SHIBLI JA, PERROTTI V
COMPARATIVE HISTOLOGICAL RESULTS OF DIFFERENT BIOMATERIALS USED IN SINUS AUGMENTATION PROCEDURES: A HUMAN STUDY AT 6 MONTHS
CLIN ORAL IMPLANTS RES, 2012 DEC;23(12):1369-76

¹¹ SCARANO A, PIATTELLI A, PERROTTI V, MANZON L, IEZZI G
MAXILLARY SINUS AUGMENTATION IN HUMANS USING CORTICAL PORCINE BONE: A HISTOLOGICAL AND HISTOMORPHOMETRICAL EVALUATION AFTER 4 AND 6 MONTHS
CLIN IMPLANT DENT RELAT RES, 2011 MAR; 13(1):13-18

¹² MARCONCINI S, GIAMMARINARO E, DERCHI G, ALFONSI F, COVANI U, BARONE A
CLINICAL OUTCOMES OF IMPLANTS PLACED IN RIDGE-PRESERVED VERSUS NONPRESERVED SITES: A 4-YEAR RANDOMIZED CLINICAL TRIAL
CLIN IMPL DENT RELAT RES, 2018 DEC;20(6):906-914

Apatos®