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Tissue origin :
Heterologous cortico-cancellous bone mix
Tissue collagen :
Degraded
Physical form :
Radiopaque granules of mineral hydroxyapatite
Composition :
100% cortico-cancellous mix
Granulometry :
1000-2000 µm
Re-entry time :
About 5 months
Packaging :
Vial: 1.0 g
Product codes :
A0210FS | 1 Vial | 1.0 g | Porcine
A0210FE | 1 Vial | 1.0 g | Equine
GMDN code : 46425

Characteristics: Apatos is a biocompatible¹, osteoconductive² biomaterial of heterologous origin with characteristics similar to mineralized human bone^3,4; it can therefore be used as alternative to autologous bone. The natural microporous consistency of Apatos facilitates the formation of new bone tissue in bone defect area⁵, accelerating the process. Apatos nanocrystalline hydroxyapatite is a mix of cortical and cancellous bone granules.
Handling: Apatos must always be hydrated and thoroughly mixed with a few drops of sterile saline; it can also be mixed with patient's blood. The mixture thus obtained should be positioned with a sterile spatula or syringe for biomaterials.
Clinical information: Filler of large maxillofacial bone defects, reconstruction or corrections in non-load-bearing indications, Apatos may be used as a drug-carrier.
Bibliography: ¹ TRUBIANI O, SCARANO A, ORSINI G, DI IORIO D, D'ARCANGELO C, PICCIRILLI M, SIGISMONDO M, CAPUTI S
THE PERFORMANCE OF HUMAN PERIODONTAL LIGAMENT MESENCHYMAL STEM CELLS ON XENOGENIC BIOMATERIALS
INT J IMMUNOPATHOL PHARMACOL, 2007 JAN-MAR; 20(1 SUPPL 1):87-91

² BRUNELLI G, SOLLAZZO V, CARINCI F, PALMIERI A, GIRARDI A, MONGUZZI R
OSTEOBIOL® INFLUENCES OSTEOGENIC DIFFERENTIATION OF ADIPOSE DERIVED STEM CELLS
EUR J INFLAMM, 2011, VOL. 9, NO. 3(S), 103-107
³ ORSINI G, SCARANO A, PIATTELLI M, PICCIRILLI M, CAPUTI S, PIATTELLI A
HISTOLOGIC AND ULTRASTRUCTURAL ANALYSIS OF REGENERATED BONE IN MAXILLARY SINUS AUGMENTATION USING A PORCINE BONE-DERIVED BIOMATERIAL
J PERIODONTOL 2006 DEC;77(12):1984-90

⁴ SCARANO A, PIATTELLI A, PERROTTI V, MANZON L, IEZZI G
MAXILLARY SINUS AUGMENTATION IN HUMANS USING CORTICAL PORCINE BONE: A HISTOLOGICAL AND HISTOMORPHOMETRICAL EVALUATION AFTER 4 AND 6 MONTHS
CLIN IMPLANT DENT RELAT RES, 2011 MAR; 13(1):13-18

⁵ IEZZI G, DEGIDI M, PIATTELLI A, MANGANO C, SCARANO A, SHIBLI JA, PERROTTI V
COMPARATIVE HISTOLOGICAL RESULTS OF DIFFERENT BIOMATERIALS USED IN SINUS AUGMENTATION PROCEDURES: A HUMAN STUDY AT 6 MONTHS
CLIN ORAL IMPLANTS RES, 2012 DEC;23(12):1369-76 EPUB 2011 NOV 2

Apatos®